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Interferon-A-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming

Similarly, the metal-responsive transcription factor MTF-1 accumulates in the nucleus upon zinc elevation, binding to metal-response elements to induce MT and other protective genes, thus forming a feedback loop that mitigates zinc excess 54,55

Monoamine oxidase (MAO) is a riboflavin protein distributed on the outer membrane of mitochondria, which catalyzes the oxidative deamination of neurotransmitters such as dopamine, phenethylamine, 5-hydroxytryptamine, and norepinephrine (Tripathi and Ayyannan, 2019)