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A fibroblast activation protein -activatable nanoagent co-delivering diethyldithiocarbamate and copper for tumor therapy and imaging

Under oxidative stress, NRF2 escapes KEAP1-mediated degradation [56], translocates to the nucleus, and activates antioxidant genes including HO-1 and NQO1

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Endothelin, which can originate from local tissues, increases intraluminal pressure by increasing outflow resistance, contracting retinal veins in particular where they exit the eye (for review of this mechanism in retina, see also 7,8 Elevated RVP has been associated with endothelial dysfunction and impaired vascular regulation, with recent studies indicating that diminished patency of blood vessels plays a key role in the increase of retinal venous pressure and subsequent edema