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Recent evidence suggests that PEGylation is generally employed to increase molecular weight and protect the payloads and/or drug nanoparticles from proteolytic degradation (Harris and Chess, 2003), thereby expanding their applicability in Alzheimer's and enabling specific designs that (i) prolong circulation timeas PEG chain can mitigate a rapid uptake by the RES (Kong et al., 2020), (ii) play a role in physical stabilityby reducing particle agglomeration and/or protein corona effect (Guerrini et al., 2018) or providing a steric stability with targeted A aggregates (Singh et al., 2022), (iii) improve BBB penetration (Kochman et al., 2026), and (v) enable controlled drug release and improved pharmacokinetics (Turjeman et al., 2015)

Statistical analyses were conducted using JMP Pro 18.0.2 and included Mixed Model ANOVA with Tukeys HSD post-hoc comparisons

Each raw material undergoes quality verification to help ensure purity, consistency, and safety.

Patients with documented cobalamin anaphylaxis history, uncontrolled hypertension, or recent acute myocardial infarction should not receive the injection without specialist review