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In this crowd, few are pushing things further than Ben Greenfield

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Nerve conduction studies revealed a severe sensory and motor axonal neuropathy in the legs (Table)

Clomipramine is a tertiary amine and undergoes two main steps of metabolism: CYP2C19 : converts clomipramine into desmethylclomipramine , an active metabolite that mainly inhibits noradrenaline reuptake