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Aborted LR3 clinical studies in oncology (late 1990s) highlighted the complexity of IGF-1R targeting: mitogenic potential on mammary and prostate tumor lines, requiring abandonment of development in favor of IGF-1R antagonists (monoclonal antibodies such as figitumumab, ganitumab, dalotuzumab) which also encountered phase III failures but enriched understanding of the IGF axis role in carcinogenesis

With direct hGH injections, especially at high doses, theres a risk of excessively elevated GH/IGF-1 levels, which may lead to side effects like joint pain, edema, insulin resistance, or carpal tunnel syndrome

HDAC inhibition by SNDX-275 (entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML

The same methods were used to assess the status of the induced gastric lesions