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Funding This work was funded by the National Natural Science Foundation of China (81670433 and 81970398), the Zhejiang Medical and Health Science and Technology Project (2020RC014 and 2023KY110), the Natural Science Foundation of Zhejiang Province (Q20H020059 and LQ20H020008), and the Science Fund for Distinguished Young Scholars of Zhejiang Province (LR22H020002)