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Liu and colleagues showed that stimulation of OA FLS with CTGF induced concentration-dependent production of the pro-inflammatory cytokine IL-6 via the CTGF-v5-JNK pathway (141)

Redox modifications of proteins of the mitochondrial fusion and fission machinery

Interestingly, Escherichia coli overexpresses this enzyme, and other microbial species that have IsmA genes have been linked to lower blood cholesterol levels (80), and it has been proposed that the coprostanol/cholesterol ratio in human feces and human serum cholesterol have an inverse relationship (81, 82)

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