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The peptides are generally studied by subcutaneous administration in animal models, while the cofactors NAD+ and glutathione are handled according to their own protocols

Disclosure of interest: No conflict of interests reported Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P1085 - ESOC25-222 STROKE AND SMALL VESSEL DISEASE DISRUPT DIURNAL RHYTHMS IN NEUROVASCULAR COUPLING: EVIDENCE FROM THE UK BIOBANK Sheng Yang 1 , Alastair Webb 1 1 Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom Background and Aims: Ischaemic stroke risk is greater in the morning and rate of infarct growth faster at night

100 g/100 L phosphate-buffered saline [PBS]/mouse), delivered intramuscularly into each thigh (50 L per thigh) three times at two-week intervals

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