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4,7 The link between hearing loss and tinnitus has been suggested to be due to a compensatory effect: the brain compensates for decreased activation of the auditory nerve (which carries signals from the cochlea to the brain) by increasing gain or signal amplification in the auditory system of the brain, as well as decreasing auditory signal inhibition, which may result in tinnitus and possibly hypersensitivity to noise

The Phase II data showed statistically significant weight loss versus placebo at several dose levels but the magnitude was modest (roughly 1.5-2.5kg over 12 weeks at optimal doses)

Note on a type of flexion fracture of the spine