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Research suggests that the TLR-endoplasmic reticulum stress-ROS signaling pathway, activated by intestinal barrier dysfunction with gut microbiota, exacerbates lung injury by promoting systemic inflammatory responses ( 3 Study on mechanism of TCM treatment of ALI 3.1 Compounds Recent studies on the use of TCM for ALI have largely focused on therapies aimed at clearing heat and detoxifying, regulating fu-organs, and resolving blood stasis