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10.1089/ars.2006.8.1865 22 KojerK.BienM.GangelH.MorganB.DickT

Hepatoprotective effects of insulin-like growth factor I in rats with carbon tetrachloride-induced cirrhosis

Methotrexate also forms polyglutamates that inhibit other enzymes such as thymidylate synthase and aminoimidazole carboxamide ribonucleotide transformylase (AICART), resulting in the accumulation of adenosine, a potent anti-inflammatory mediator