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Solvent A consisted of 94.9% (v/v) water, 5% (v/v) acetonitrile, and 0.1% (v/v) formic acid, and solvent B was composed of 5% (v/v) water, 94.9% (v/v) acetonitrile, and 0.1% (v/v) formic acid

SOD plays an important role in antioxidant defenses, by converting superoxide into H 2 O 2 , which can then be further detoxified by other enzymes such as catalase.[182] There are three major classes of SOD, which are distinguished by the metal catalyst, which can be copper (Cu), Zn, Mn, iron, or nickel

GSH depletion (e.g., erastin treatment) or GRX5 silencing induces iron overload and ferroptosis, sensitizing cancer cells to chemotherapy (66)

10.3390/molecules27217604 5 Al AminM.DehbiaZ.NafadyM