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Considering the recent X-ray crystallography and cryo-EM data, which revealed that GSH and Glu could bind to different domains of GLR3.4 for ion channel activation 30 , it would be intriguing to investigate whether GSH binds to GLR3.3 and further determine the potential relationship between GSH and Glu in activating GLR3.3

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In women with POCS, NAC at a dosage of 1200-1800 mg/day appears to be beneficial, while metformin treatment appears to be more successful [79]