glutathione high or low in acetaminopen overdose usmle π One question. One concept. One point on exam day. Acetaminophen overdose? You should recognize the antidote seconds, not after rereading a textbook. Train your brain with active recall and build Too much paracetamol = dangerous
Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which N Acetylcysteine & Paracetamol Poisoning Rescue
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