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The interplay among iron accumulation, oxidative stress, and neuroinflammation can create vicious cycles that reprogram cellular metabolism and disrupt the critical metabolic coupling between neurons and glial cells

Ghazaleh N, Zwaag W, Clarke S, Ville DVD, Maire R, Saenz M

In lupus-prone mice, 4-PBA reduces splenomegaly, anti-dsDNA antibodies, and inflammatory cytokines and alleviates lupus nephritis by decreasing albuminuria, renal inflammation, and immune complex deposition