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So far, Sil1 has been recognized as the gene responsible for about half of the MSS cases, while the trigger for the remaining ones is still unknown

(PubMed) Sherman PM, Ossa JC, Johnson-Henry K

Arch Biochem Biophys 228:112 Pinto MC, Mata AM, Lopez-Barea J (1985) The redox interconversion mechanism of Saccharomyces cerevisiae glutathione reductase