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Mascarenhas M, Habeebullah S, Sridhar MG (2014) Revisiting the role of first trimester homocysteine as an index of maternal and fetal outcome

When to seek medical advice: Persistent or worsening injection site reactions (increasing redness, warmth, or discharge suggesting infection) Severe or persistent headaches Chest pain or palpitations Unexplained muscle weakness or cramps New or worsening neurological symptoms despite treatment Unexpected bleeding or bruising For non-emergency concerns, contact your GP or NHS 111

Below, well look at a few of the more notable changes (percentage change amounts appear in Table 1)