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Catalysis is dependent on a cubane [4Fe-4S] 2+ cluster which is required to facilitate the elimination of the hydroxyl group from C 3 position of citrate (Gardner, a group in the cluster is required for coordination of the OH group on the C 3 prompting its elimination and the genesis of a cis -aconitate intermediate (Lauble and Stout, 1995)

We would like to thank Blythe Argyle for assistance with the replication and mitochondrial morphology assays

Identification and characterization of two mutations in galactosyltransferase I gene

CCL2 and lactate from chemotherapeutics-treated fibroblasts drive malignant traits by metabolic rewiring in low-migrating breast cancer cell lines