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87 Aspartate in cancer TP53 is a gene with the highest mutation frequency in human cancer

O.BensonD

A.OBrienJ.BlackS.ChenC.DeCarliC.ErkinjunttiT.et al (2017)

However, several drugs, including teprotumumab and BIIB-022, which target IGF-1R, have not shown good therapeutic effects in clinical trials, possibly due to the lack of reliable IGF-1R inhibition biomarkers