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Anticancer effect of pan-PI3K inhibitor on multiple myeloma cells: shedding new light on the mechanisms involved in BKM120 resistance

This is particularly relevant as the BBB represents a major challenge in CNS drug delivery, often preventing neurotherapeutic agents from effectively reaching the brain

Melatonin-induced inhibition of the PI3K/AKT/mTOR pathway has caused a reduction in glucose uptake and ATP production and therefore has controlled the Warburg effect

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