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It is vital for synthesizing glutathione, an intracellular antioxidant that protects cells from toxins

1 2 "GSTZ1 glutathione S-transferase zeta 1 [Homo sapiens (human)] - Gene - NCBI"

2010 Dec;30(4):328-339 NF-kB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy

In addition to Ca 2+ , S100A2 also binds to Zn 2+ with higher affinity, and the binding affinity of S100A2 to calcium is significantly reduced upon binding to zinc (42)