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This mechanism involves the addition of lipid peroxyl radicals (ROO ) to the carotenoid (CAR) polyene chain, resulting in the formation of a carbon-centered radical from a carotenoid molecule (ROO-CAR )

doi: 10.1056/NEJMoa2510095 100 AdewaleATFalk LibbyEFuLLenzieABoitetERBirketSEet al

Pang P, Abbott M, Abdi M, Fucci QA, Chauhan N, Mistri M, Proctor B, Chin M, Wang B, Yin W, Lu TS, Halim A, Lim K, Handy DE, Loscalzo J, Siedlecki AM (2018) Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function

Compare to healthy cells, cancer cells are characterized by increased formation of ROS and therefore to avoid ROS-induced cell death, cancer cells restore their ROS homeostasis by increasing their antioxidant capacity (Valko et al