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These findings highlight coppers dual roles as both an essential cofactor and a potential toxicant, depending on its cellular levels

While dietary restriction has shown promise in attenuating aging biomarkers and extending healthspan by modulating these pathways, its clinical application faces two critical challenges

Krivoy A, Onn R, Vilner Y, Hochman E, Weizman S, Paz A et al (2017) Vitamin D supplementation in chronic schizophrenia patients treated with clozapine: a randomized, double-blind, placebo-controlled clinical trial

The looping causes bending and distortion of the ori-Lyt DNA, facilitating unwinding of the DNA sequence (Wang et al., 2006 )