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Leveraging reinforcement-learning frameworks, evolutionary algorithms, and Bayesian optimization, AI can guide the rational integration of complex payloadsincluding siRNAs, antisense oligonucleotides, small-molecule antivirals, immunomodulators, or even CRISPR/Cas genome-editing componentsinto next-generation nanoplatforms capable of addressing HBV cccDNA persistence or HCV genotype-specific replicative kinetics [215,216,217]