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Histologic features of melasma include an increase in the content of both epidermal and dermal melanin, but the quantity varies with the intensity of hyperpigmentation

For instance, these measures include payment schemes, commercialization awards, patent purchases, and publicprivate partnerships in which public funding helps R&D at different development stages in pharmaceutical and biotech companies [61]

Curcumin exhibits several pharmacological attributes that include anti-inflammatory, anticancer, antimutagenic, anti-arthritic, and antioxidant effects [106]