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Eur J Pharmacol 543(13):4047 Al-Rawashde FA, Wan Taib WR, Ismail I, Johan MF, Al-Wajeeh AS, Al-Jamal HAN (2021) Thymoquinone Induces downregulation of BCR-ABL/JAK/STAT pathway and apoptosis in K562 leukemia cells

when underexposure is expected (for example, in ultrarapid metabolizers), cautiously increasing the dose within safety limits or selecting an alternative agent with less dependence on the affected metabolic pathway

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