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These findings provoke interesting primary questions as to the possible origins of PD-associated alpha-synuclein misfolding from within autonomic nerve fibers of the gut

Lewy bodies in the remaining neurons of substantia nigra and other affected brain regions provide the most discriminating pathological observation in PD (Hassler et al., 1960

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Hexachlorobutadiene, utilized in the rubber industry and pesticide manufacturing, produces metabolites that accumulate in bladder cells and induce gene mutations by binding to DNA, thus posing a potential risk for bladder cancer (Zhang et al., 2019