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The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity

Just so you know, my urine is a normal color and there doesnt seem to be any sign that I am excreting excess B12 (judging by the urine color) Believe me, I know there may be other factors causing ongoing symptoms, and the symptoms I have mimic so many other health issues, but if you think it is worth bumping up the dosage please let me know With that being said, I am addressing the plethora of symptoms, and awaiting some results and guidance from my holistic practitioners to sort things out

Method development and validation

The trade-off is that a vial with a larger volume takes up more space and is used up faster