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Regular monitoring and adjustment of the dosage are essential to prevent deficiency and maintain optimal health

This bridge appears to further stabilize the molecule and may increase its resistance against degradation in various environments, including stomach acid

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While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)