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B vitamins are coenzymes needed for energy production, proper nerve function, normal vision and skin health, digestive system health, protein metabolism, carbohydrate metabolism, red blood cell formation, DNA and RNA synthesis, fatty acid synthesis, amino acid synthesis and the manufacture of sex and stress related hormones

The most significantly enriched gene sets with negative enrichment scores primarily involved mitochondrial and ribosomal processes and included mitochondrial inner membrane and ribosomal subunit (Fig