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On timing, the practical answer is consistency over cleverness

identified that caveolin-1, a membrane protein that plays a role in cell signaling and material transport, was significantly downregulated in the hippocampus of diabetic mice, and its overexpression can mitigate the cognitive dysfunction linked to DM by modulating neuronal ferroptosis and maintaining mitochondrial homeostasis [60]

have described the identification of novel candidate genes for late onset PD