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Although not as extensively studied as the previously mentioned antioxidants, melatonin has been shown to exhibit protective effects against PM and ozone

Such targeted therapeutic therapies would bring about favorable outcomes such as improvements in core and co-occurring symptoms

It also impairs endothelial tube formation in vitro, decreases HIF-1 stabilization and nuclear localization under hypoxic conditions, and inhibits MMP-2 and MMP-9 activity