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For example, the synthesis of FPP and geranylgeranyl pyrophosphate (GGPP) is essential for protein prenylation, a post-translational modification required for the function of many signaling proteins, some of which belong to the Ras small GTPase superfamily (e.g., the Ras, Rab, and Rho), including over 150 proteins regulating many cellular functions, such as membrane trafficking, cell proliferation, survival and differentiation [93]

This approach, however, has only been studied in mouse models

Disparities were evident in evaluation (39%) and listing (53%) compared to non-Hispanic whites (51% and 64%, respectively)

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