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According to meta-analysis data, hypothyroidism occurs in about 3.8% of patients treated with anti-CTLA-4, 3.9% with anti-PD-L1, 7.0% with anti-PD-1, and 13.2% with combination therapy

The mode of action of -carotene in murine melanoma cells may conclude the blockage of Bcl-2, p53, and caspase-3, which then stimulates apoptosis and potency of -carotene upon tumor-specific angiogenesis, due to which tumor growth is affected

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