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Extracellular NM released from degenerating neurons is phagocytized by microglia, activating inflammatory responses and propagating neurodegeneration (265)

Upregulation of this transporter effectively sequesters dietary vitamin B12 so it cannot be absorbed from the gut

The 2-oxoglutarate carrier is S-nitrosylated in the spinal cord of G93A mutant hSOD1 mice resulting in disruption of mitochondrial glutathione transport