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Description

The metal ion hypothesis of Alzheimers disease and the anti-neuroinflammatory effect of metal chelators

Nature 614 , 635648 (2023)

Author contributions GNT: Writing original draft, Project administration, Visualization, Formal analysis, Funding acquisition, Supervision, Methodology, Software, Data curation, Writing review & editing, Validation, Investigation, Resources, Conceptualization

Some depressed patients were also reported to have enlarged adrenal glands (253,254) and impaired negative feedback with the hypercortisolemia, thereby suggesting that the level of impairment is at the glucocorticoid receptor-dependent negative feedback, either centrally or at the level of pituitary (255,256)