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Figure 3: Sample collection and handling protocol for accurate eicosanoid quantification LC-MS/MS Methods for Eicosanoid Profiling Eicosanoid quantification by LC-MS/MS presents analytical challenges distinct from routine lipidomics

39 Consistently, this vicious cycle can further amplify the carcinogenic signal

In one crucial area called lipid metabolism, 34 genes (or 14% of the total) were upregulated by up to 41-fold and 19 genes (or 8% of the total) were downregulated by up to 3-fold