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Accordingly, women who receive hormone replacement therapy are less likely to develop venous leg ulcers or pressure ulcers than untreated controls, and anti-estrogen therapies, such as tamoxifen or aromatase inhibitors, are also correlated with poor wound healing (Thornton, 2013)

Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma

Therefore, it seems highly plausible that oxidative stress in the brain compromises biochemical integrity of the hippocampus and the amygdala