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The increased red pulp cell count within Chitosan@DOTAGA-treated mice may be evidence of either an altered blood supply, which is in agreement with the other histopathological observations of mice organs made within this study, or an intensification of the hemopoiesis suffering due to heavy metal exposure 53

Distribution primarily involves the face including the periorbital region, muzzle, perioral area (commissures and lip margins), chin, and ears