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The therapeutic effect of KDS12025 in neurodegenerative mouse models, including AD, PD, and ALS Reactive astrocytes play a pivotal role in neurodegeneration by promoting oxidative stress and neuronal damage, which are hallmarks of AD, PD, and ALS pathology

In addition, we show that inhibition of ferroptosis can result in attenuation of A-related lipid peroxidation and an increase in the expression of iron storage proteins in brain cortical organoids differentiated from iPSCs of AD patients compared to their isogenic controls

Dewanjee S, Chakraborty P, Bhattacharya H, Chacko L, Singh B, Chaudhary A, et al

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