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Melatonin could inhibit the endoplasmic reticulum stress and insulin resistance in T2DM through inhibition of apoptosis signal-regulated kinase 1 (ASK1), a protein that mediates apoptosis and cell death [64]

Levodopa monotherapy produced drowsiness in the first round of 131 PD patients and restricted the dosage of levodopa in 14% of patients (Lesser et al., 1979)