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These groups include vegetarians, vegans, and persons with pernicious anemia, gastrointestinal disorders and alcohol abuse problems

Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

B12 supports the energy metabolism that underpins all metabolic processes

Asbaghi O, Kelishadi MR, Larky DA, Bagheri R, Amirani N, Goudarzi K, Kargar F, Ghanavati M, Zamani M