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The STAT3 signaling pathway primarily contributes to immune suppression and is typically stimulated by cytokines such as interleukin-6 (IL-6), IL-10, and certain growth factors, including epidermal growth factor (EGF), transforming growth factor- (TGF-), and insulin-like growth factor (IGF) (309, 310)

Raw spinach retains the highest glutathione content, but light steaming can make other nutrients more bioavailable while preserving most of the glutathione

Glutathione ethyl and monoethyl esters are another class of GSH prodrugs that enhance cellular uptake via ester bond-facilitated membrane permeation

CD44-AF647 (BioLegend, 103018, clone IM7, lot B317762, FCy, 1:100, Ms)