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Description

Hughes RE

The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells

To address this, combining gene-editing tools (e.g., CRISPR or RNAi) with conventional therapies offers a promising solutionenabling precise disruption of redox-regulating genes (e.g., NOX4 and HIF1) while leveraging the broad cytotoxicity of chemotherapy