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Correlations between TYR, TRP, and some purines may originate in the diet or other common organism-wide influences, but some of these appear to be lost as these compounds undergo further transformations along their respective pathways

Spicer JD, Shewale JB, Bott MJ, Jones DR, Vaporciyan AA, Darling GE, Swisher SG , Sepesi B

doi: 10.1186/1472-6815-13-12 216 Smith-VaughanH.ByunR.NadkarniM.JacquesN

However, it is important to emphasize that cells can carry out a premature mitotic exit known as mitotic slippage, which is the major mechanism of rescue cells from MTAs, limiting the therapeutic efficacy of these drugs [79]