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503 Targeting IL-31 Monoclonal antibodies, including nemolizumab, a humanized monoclonal antibody targeting IL-31 receptor A (IL-31RA), relieve itching symptoms and IL-31 signal transduction in the pathogenesis of AD

These conditions are rising for many reasons including an aging population, long term stress, unhealthy eating habits, sleep issues, lack of physical activity, and nutritional deficiencies

Periorbital study (28 days) : Palmitoyl pentapeptide-4 cream (0.005%) applied twice daily to the periorbital area decreased fold depth by 18%, fold thickness by 37%, and improved skin firmness by 21%