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Description

Long-chain-fatty-acidCoA ligase 4 (ACSL4) incorporates PUFAs into lipid membranes and increases the susceptibility of tumor cells to ferroptosis [6]

Pharmacology 74, 5764

Similarly, in hepatocytes exposed to lipotoxic stressors, zinc supplementation reduces cytotoxicity by mitigating ER stress and enhancing antioxidant defense, demonstrating its capacity to preserve proteostasis and limit inflammatory responses 178