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GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues

The main problem may contribute to the limitations of the theoretical perspective and the limitations of detection methods

it can reduce H 2 O 2 in the presence of GPx by the reduction of its thiol group and keeps thiol groups from Hb, enzymes and membrane proteins in the reduced form [13], which is very important for the preservation of their functions, once oxidation of these groups can lead to functional and structural cellular modifications

Lifelong Dependency and Psychological Burden Over time, many patients begin to recognize that their condition requires lifelong management rather than resolution