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Takahashi, H

Bhardwaj et al , Asian Journal of Andrology Hesham Nabil, et al , Australian Journal of Basic and Applied Sciences Agarwal A, et al , Fertility Sterility And many of the studies I am about to discuss also corroborate these findings but report of other aspects of the relationship to glutathione (GSH) and sperm Garrido N et al published research in Fertility Sterility showed that intracellular (inside the cell) Glutathione concentrations are lower when severe sperm morphology is present, establishing the connections between high sperm morphology rates and high ROS, and the need for glutathione (GSH) supplementation

Furthermore, these authors reported adverse effects of an increased rate of mitochondrial hydrogen peroxide production ( Alternatively, there is the notion that NO advantageously affects mitochondrial efficiency ( NO and redox state Not only does NO regulate mitochondrial function and biogenesis via interactions with signaling molecules and the electron transport chain, but it also regulates the production of mitochondrial free radicals (reactive oxygen species and reactive nitrogen species) (Figure 3)

Additionally, genetic testing and antioxidant application might help identify GSSD and improve the prognosis