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Limitations: Research is primarily manufacturer-sponsored

The Nrf2 pathway of SFN is essential for providing the neuroprotective advantages against several brain illnesses through multiple pathways and by activating results in enhanced expression of multiple downstream molecules, i.e., NAD(P)H quinone oxidoreductase-1 (NQO1), Heme oxygenase-1 (HO-1), Glutathione peroxidase-1 (GPx-1), and Gamma-glutamylcysteine synthetase ( -GCS), that provide defense against oxidative stress (95)

Nevertheless, the current understanding of the potential association between CM and the gut-brain axis (GBA) is based solely on indirect inferences drawn from existing literature

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